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Multiple freeze-thaw cycles, which can happen inadvertently in a poorly calibrated refrigerator, will progressively destroy the remaining active peptide until the preparation is essentially inert

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Liraglutide, a once daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)